在这部杀死我吧，苏珊娜剧情/喜剧/爱情片中,埃里吉奥（盖尔·加西亚·贝纳尔 Gael García Bernal 饰）是一个非常大男子主义的人，在和妻子苏珊娜（薇洛妮卡·恩切圭 Verónica Echegui 饰）的日常相处过程中，他事事都要说了算，处处都要高苏珊娜一头，随着时间的推移，一再忍让的苏珊娜终于决定反击，她的方式是毫无预兆一声不响的离家出走了。
实际上，埃里吉奥是非常的爱自己的妻子的，只是他的性格令他不知道该如何表达自己的感情。埃里吉奥踏上了寻找苏珊娜的旅途，却愤怒的发现，离开了自己后，苏珊娜似乎和一个名叫斯拉米尔（比约恩·西鲁·哈瑞森 Björn Hlynur Haraldsson 饰）的诗人打得火热。经过了重重的波折，埃里吉奥和苏珊娜好歹是复合了，但他真的能改掉自己的臭毛病吗？
One morning Eligio (Gael García Bernal) wakes up to discover that his wife -Susana- has left him without a word. He is clueless as to her reasons or whereabouts. Ciudades Desiertas takes us on Eligio's quest to find and recover the woman he loves. His voyage will take him from Mexico City to a university in Iowa where he finds a Susana who's moved on and is no longer willing to accept his childish behavior. Eligio will try to charm his way through this situation, but her determination plus the foreign land and culture he finds himself in, will force him to face his own demons and contradictions. It is a journey of late growth; funny, painful and -in an unconventional sort of way- very romantic.
做爱是爱情里解决争吵的的一种自然而有效的途径。
