在这部鬼马小精灵之恐怖学校喜剧/动画/儿童/奇幻/冒险片中,故事发生在位于缅因州的一幢古老的庄园之中，这里居住着胖子（比利·维斯特 Billy West 配音）、瘦子（约翰·迪·玛吉欧 John DiMaggio 配音）、斯特里奇和可爱的卡斯柏（戴文·沃克海瑟 Devon Werkheiser 配音），它们均为徘徊在庄园之内的古老幽灵。卡里根是庄园的主人，他恨透了这些常常给他找麻烦的调皮捣蛋的幽灵们，因此，卡里根找来了鬼怪研究专家哈维博士，希望接住他的力量彻底消灭这些讨厌鬼。
哈维博士带来了自己的女儿凯特，让大家没有想到的是，凯特竟然和卡斯柏它们成为了好朋友。哈维博士发现了一台能够令人起死回生的机器，贪婪的卡里根为了得到这宝贝，甚至把自己也给变成了幽灵。
In CASPER'S SCARE SCHOOL, Casper has a new assignment: get in touch with his spooky side and start scaring "fleshies" OR ELSE! It's a tough enough challenge for the world's friendliest ghost. But when he goes to Scare School to learn his craft, he uncovers a plot by Alder and Dash, the cruel, two-headed headmaster, to take over the world. With only himself and his misfit pals Ra, a mummy with "unraveling issues," and Mantha, a zombie who can't keep her limbs on, the odds are stacked against him. But what Alder and Dash don't realize is that the power of friendliness is greater than any evil plot, and when friends work together nothing can stop them.
