在这部死岛历险记惊悚/恐怖片中,百万富豪金先生（麦柯姆·麦克道威尔 饰演）带著工程师来到纽约曼哈顿周围的哈特岛，准备出席为岛上贫苦的居民建造新城的破土典礼。 当他在掘土时，却挖出变种大苍蝇，一行人计划搭渡轮重返纽约时，这群变蝇虫开始攻击人群，而渡轮船长也成蝇虫口下的受害者，在无船可搭的情况下，一群人被封锁在岛上，无处可逃……
The people of New York have been burying their unknown dead on Hart Island since 1869. Now real estate tycoon Rupert King wants to build what he calls "Hope City", supposedly to help the poor and homeless of the city "get a leg up", on this same island, with no thought of the current million or so "residents". Accompanied by a New York cop looking for a missing girl's body and some reluctant employees of the Department of Corrections, King makes his way to the island for the ground-breaking ceremony. But when his personal assistant goes missing, and night falls on the island, dark secrets are revealed, not only about the island itself, but King's "noble" plans for it as well. And the island's residents, with their souls in the form of countless and lethal flies, have no intention of being ignored.
