在这部再见，绝望先生剧情/喜剧/动画片中,樱花飞舞的春天，前往学校途中的少女风浦可符香，发现在樱花树上吊的男子。匆忙之下将男子救下的她，却得到了“真死了怎么办？！”的奇怪质问。面对这名超消极男子，乐观的可符香提出了“上吊的人只是想增高”的无厘头解释，并以“桃色部长”的花名称呼这名男子。
离开男子的风浦可符香来到教室，却发现刚刚见面的男子，正是学校来的新教师——糸色望。因汉字合起来是“绝望”而被学生称为“绝望老师”的望、口头禅是“绝望了！对xx的世界绝望了”。他与2年へ班32名学生的爆笑校园生活就此开始。
Nozomu Itoshiki is a high school teacher who always looks on the negative side of life, constantly left in despair from the troublesome issues society presents. He constantly tries to kill himself to free himself from this cruel world, but is unable to do so because of his class of students, many of whom are more bizarre than he is. There is Chiru who needs to organize everything perfectly, the mute but abusive Meru, Matoi who loves stalking people, and a host of other cute but crazy students the most frightening of which is the optimistic but oblivious Kafuka, whose enthusiasm is over-the-top and lethal to anyone she meets. With all the antics his students carry on, can Nozomu ever manage to find something good in life?
等待，希望与那一点点感动。绝望就是萌化的太宰治。【转】论《绝望先生》及风浦可符香的哲学---超乐观与超悲观。不绝望的动画·《绝望先生》。2年へ班其实就是一个人...。再见，糸 色望先生。绝望少女达。绝望啦！！~~。读图时代的深刻。无意中嘲讽着这一切。
