在这部蜜月玩很大喜剧片中,哈利·弗路得婚礼快要进行了，结果发现未婚妻在和别人疯狂做爱。无奈，哈利·弗路得的铁哥们博勒加德·彭伯顿宣布：婚礼取消。但已经定下来的海岛蜜月游无法取消，于是哈利·弗路得决定和博勒加德·彭伯顿一起去旅游。在海岛上，两人无意中介入到一起贩毒案件中，甚至差点被毒贩杀死。幸亏博勒加德·彭伯顿机智聪明，加上FBI在毒贩中安插的内线，终于顺利破案。
For Harry Fluder, life was working out exactly how he thought it was supposed to. He had a great job, loyal friends, and the perfect fiancee. However, finding one of his maybe not-so-loyal friends doing a "great job" with his perfect fiancee, was not part of the plan. After cancelling the wedding, Harry, in a drunken stupor, ponders how everything that was so right could have gone so wrong, meanwhile Bowie, Harry's best man, gets a flash of inspiration. Instead of also cancelling the amazing tropical honeymoon, why don't the two of them go instead, on an epic "homie-moon." What is supposed to be a refreshing weekend of rest and relaxation turns into an all-out bonkers adventure of epic proportions. Harry and Bowie will have the time of their lives, if they can just survive this Random Tropical Paradise.
